Multiple Sclerosis

AMA003 is a reverse vaccine for the treatment of Multiple Sclerosis (MS). MS is an autoimmune disease where self-reactive T lymphocytes selectively attack and destroy oligodendrocytes leading to demyelination of axons in the brain and spinal cord that finally results in functional disability and premature death. Myelin components such as myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) are considered to represent the main primary self-antigens involved in the chronic autoimmune destruction of oligodendrocytes. To date, MS cannot be cured. The current treatment options include the use of immune-suppressing antibodies to prevent the recurrence of acute attacks and to delay disease progression. However, long-term use of general immuno-suppressing drugs coincides with severe adverse side effects. Using AMA003 we intent to restore the immune tolerance to MOG and MBP and thereby cure the patients from the disease.